Anderlecht vs Lyon Prediction & Betting Tips | 16/09/2026

Anderlecht vs Lyon Prediction and Betting Tips | 16 September 2026

Bojan Jovanovic • Football expert

14 September 2026 • 09:51 UTC • 1 min read

Anderlecht vs Lyon Prediction and Betting Tips 16 September 2026

All eyes will be on Lotto Park when Anderlecht welcome Lyon for their Europa League round-one clash, with the Belgian side hoping to carry their domestic momentum onto the European stage. Anderlecht edged Mechelen 1-0 last time out after eliminating Kairat in the playoffs. Camara, Hey and Sardella remain sidelined, but the hosts have won 80% of their last 10 home matches, scoring 1.80 goals per game and conceding only 0.60.

Lyon enter the competition after failing to overcome Fenerbahce in the Champions League playoffs. The French outfit have endured inconsistent form, winning just 30% of their last 10 matches, while their away record shows only a 20% win rate. Malick Fofana has departed for Sunderland, while Julien Duranville is unavailable through injury. Lyon average 1.01 xG away from home, although their European experience could make this a competitive encounter.

As Anderlecht have turned their Lotto Park into a real fortress, Home Win should be considered, alongside Over 1.5 and Over 2.5 goals (all four previous H2Hs produced at least three goals).

This Europa League match will be played on Wednesday 16 September 2026 at 20:00.

What is our Anderlecht vs Lyon prediction?

Our prediction for this match: Anderlecht 2 - 1 Lyon

Anderlecht vs Lyon Betting Tips

Correct Score: 2-1 @ 1000 Odds
Both Teams to Score (BTTS): Yes @ -163 Odds
Over / Under 4.5 Goals: Under 4.5 Goals @ -600 Odds
Over / Under 3.5 Goals: Under 3.5 Goals @ -225 Odds
Over / Under 2.5 Goals: Over 2.5 Goals @ -138 Odds
Over / Under 1.5 Goals: Over 1.5 Goals @ -450 Odds
Anytime Goalscorer: Keito Nakamura @ 140 Odds
First Goalscorer: Keito Nakamura @ 500 Odds
To be Booked: Andrew Omobamidele @ 240 Odds
Asian Handicap: Anderlecht +0.5 @ -160 Odds
European Handicap: Anderlecht +1 @ -450 Odds
Shots on Target (Home): Over 4.5
Shots on Target (Away): Over 2.5
Shots on Target (Total): Over 7.5
Total Corners: 9 - 11 @ 162 Odds
Double Chance: 1X @ -175 Odds
Draw No Bet: Anderlecht to Win @ 110 Odds
Half Time/Full Time: Anderlecht to Win/Anderlecht to Win @ 350 Odds
Clean Sheet: Lyon - No @ -350 Odds

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Anderlecht Team Form and Stats

Form	Results	Points Per Game
Overall	wwwlwwlwdw	2.20
Home	wwwwd	2.60
Away	wlwlw	1.80

Stats	Overall	Home	Away
Win %	70%	80%	60%
Average Goals Per Game	2.10	2.40	1.80
Scored	1.40	1.80	1.00
Conceded	0.70	0.60	0.80
BTTS	20%	40%	0%
Clean Sheets	60%	60%	60%
Failed to Score	30%	20%	40%
Expected Goals	1.69	2.06	1.32
Expected Goals Against	1.14	0.88	1.39

Lyon Team Form and Stats

Form	Results	Points Per Game
Overall	lllwdwldwd	1.20
Home	lwldw	1.40
Away	lldwd	1.00

Stats	Overall	Home	Away
Win %	30%	40%	20%
Average Goals Per Game	2.50	2.80	2.20
Scored	1.20	1.60	0.80
Conceded	1.30	1.20	1.40
BTTS	50%	60%	40%
Clean Sheets	30%	20%	40%
Failed to Score	30%	20%	40%
Expected Goals	1.43	1.97	1.01
Expected Goals Against	1.25	1.17	1.31