MLS Predictions

Toronto FC

Toronto FC

Prediction:
1-3

Match Time & Date:

27 September 2025

22:30

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Inter Miami

Inter Miami

BMO Field will be the centre of attention when Toronto FC and Inter Miami lock horns in an eagerly-awaited MLS game. The Reds missed out on a place in the MLS playoffs, but their pride will be at stake in Saturday’s clash. All Gomis, Kerr, Long, Monlouis, and Wingo are out of contention with injuries. Anyhow, Toronto boss Robin Fraser is expected to mix the squad.

... Read More...

This match will be played on 27 September 2025 at 22:30

Los Angeles FC

Los Angeles FC

Prediction:
3-2

Match Time & Date:

22 September 2025

02:00

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Real Salt Lake

Real Salt Lake

After crushing Real Salt Lake 4-1 in midweek, Los Angeles FC will be aiming to record yet another triumph over the Royals when the two teams face each other at BMO Stadium. The Black and Gold have been scoring goals for fun of late and we predict that they will stick to their attacking style of play against Real Salt Lake. A man to watch in the home team will be Heung-Min So... Read More...

This match will be played on 22 September 2025 at 02:00

Austin FC

Austin FC

Prediction:
1-1

Match Time & Date:

22 September 2025

00:00

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Seattle Sounders

Seattle Sounders

Austin will be aiming to recover from a 2-0 loss to FC Dallas when they face Seattle Sounders in Monday’s MLS game. Los Verdes are eager to stay in the playoffs berth, but this match will be anything but a walk in the park. Brandon Vazquez remains in the recovery room with a knee injury, while forward Myrto Uzuni is pushing for a recall to the starting XI.

The Soun... Read More...

This match will be played on 22 September 2025 at 00:00

San Jose Earthquakes

San Jose Earthquakes

Prediction:
3-1

Match Time & Date:

21 September 2025

03:30

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St Louis City

St Louis City

San Jose Earthquakes take on St. Louis City SC at PayPal Park in Sunday’s MLS clash between two sides heading in different directions. San Jose are reeling from back-to-back defeats, a 1-3 loss to Austin FC followed by a 2-4 setback against Los Angeles FC, and their defensive weaknesses have been heavily exposed. Still, the Quakes remain in the thick of the playoff race an... Read More...

This match will be played on 21 September 2025 at 03:30

Los Angeles Galaxy

Los Angeles Galaxy

Prediction:
1-2

Match Time & Date:

21 September 2025

03:30

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Cincinnati

Cincinnati

Los Angeles Galaxy play host to FC Cincinnati at Dignity Health Sports Park as the Eastern Conference races heat up. The Galaxy have nothing left to play for in terms of playoff qualification, having already missed out on a top-nine finish, but pride will be at stake in front of their supporters. Despite a disappointing campaign, LA remain a team capable of producing flashes... Read More...

This match will be played on 21 September 2025 at 03:30

Sporting Kansas City

Sporting Kansas City

Prediction:
2-3

Match Time & Date:

21 September 2025

01:30

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Vancouver Whitecaps

Vancouver Whitecaps

Sporting Kansas City and Vancouver Whitecaps take on each other in what could be a playoff-defining match. Kansas City aim to keep their playoff hopes alive, but they enter this with a shaky run, having suffered four defeats in their previous five league matches. Vancouver want to build on a thrilling 7-0 win over Philadelphia Union, riding high and confident. Sporting are m... Read More...

This match will be played on 21 September 2025 at 01:30

Minnesota United

Minnesota United

Prediction:
1-1

Match Time & Date:

21 September 2025

01:30

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Chicago Fire

Chicago Fire

Minnesota United take on Chicago Fire at Allianz Field in a crucial MLS showdown. Minnesota have already booked their place in the playoffs, but they surely want to overtake San Diego FC for top spot in the Western Conference. The hosts, however, will be without Hassani Dotson (meniscus injury) and Ho-Yeon Jung (season-ending torn ACL).

Chicago Fire, on the other sid... Read More...

This match will be played on 21 September 2025 at 01:30

Houston Dynamo

Houston Dynamo

Prediction:
1-1

Match Time & Date:

21 September 2025

01:30

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Portland Timbers

Portland Timbers

Houston Dynamo and Portland Timbers take on each other at Shell Energy Stadium in the race for playoff positions. The Dynamo are desperate to climb into the top nine, producing far better displays in front of home fans compared to their away performances. They showed character in recent matches, and even though Artur is unavailable due to suspension, the Orange Crush still l... Read More...

This match will be played on 21 September 2025 at 01:30

FC Dallas

FC Dallas

Prediction:
1-0

Match Time & Date:

21 September 2025

01:30

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Colorado Rapids

Colorado Rapids

FC Dallas play host to Colorado Rapids in a six-pointer at Toyota Stadium. The Toros boosted their playoff hopes with a confidence-building 2-0 win over state rivals Austin FC, and they will be aiming to keep momentum going in front of their supporters. The return of goalkeeper Michael Collodi from suspension provides extra stability at the back, while Dallas’ attacking un... Read More...

This match will be played on 21 September 2025 at 01:30

Orlando City

Orlando City

Prediction:
2-1

Match Time & Date:

21 September 2025

00:30

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Nashville

Nashville

Orlando City play host to Nashville SC in what promises to be an exciting MLS clash. The Lions are eager to cement their spot in the playoffs berth as they eye their third consecutive win at home. Their attacking line looks stronger than ever with key forward Luis Muriel back from suspension, and confidence is high following recent victories. Orlando’s defense has also tig... Read More...

This match will be played on 21 September 2025 at 00:30

Inter Miami

Inter Miami

Prediction:
4-1

Match Time & Date:

21 September 2025

00:30

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DC United

DC United

Buoyed by a 3-1 win over Seattle Sounders, Inter Miami will look to give fans yet another reason to celebrate when they face DC United at their Chase Stadium on Sunday morning. The Herons are sitting in sixth place in the Eastern Conference, but you should bear in mind that they have three games in hand. As always, a man to watch in the home team will be Leo Messi, who score... Read More...

This match will be played on 21 September 2025 at 00:30

Columbus Crew

Columbus Crew

Prediction:
2-0

Match Time & Date:

21 September 2025

00:30

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Toronto FC

Toronto FC

Following a 3-2 loss at New York City, Columbus Crew will look to get back on course in the Major League Soccer when they face Toronto FC on Sunday. Columbus are determined to retain their spot in top seven and we predict that they will adopt an attack-oriented approach against Toronto FC. There are no fresh injury worries in the home team, but all Rossi, Camacho, and Zawads... Read More...

This match will be played on 21 September 2025 at 00:30

When Do We Release MLS Predictions?

With the majority of MLS games being scheduled on the weekends, the MLS predictions and football tips will often be up at the start of the week on either Monday or Tuesday. For midweek games there will be information available during the weekend, in order to give punters a suitable amount of time to analyse the teams.

A lot of people tend to believe that you can telegraph what’s going to happen in Major League Soccer more so than you can elsewhere, but we honestly believe that couldn’t be any further from the truth.

This is an exciting league full of many twists and turns, and because it’s so young, the possibilities are endless for what the next few years could hold.

MLS Predictions by FootballPredictions.com

Major League Soccer is the premier football league in the United States of America, and it’s been that way ever since the first season came to fruition in 1996. As a part of the CONCACAF, the MLS plays host to three Canadian teams with the rest stemming from the United States, currently being 24 operational teams on a week to week basis.

Summers are for MLS

The regular season runs from March all the way through until October, with the team with the best record being given the Supporters’ Shield. From that point on 14 teams compete in the MLS Cup Playoffs, before eventually being dwindled down to two: who then compete in the MLS Cup.

The MLS keeps on rising

The league struggled in its first few seasons but has really come firing out of the blocks in the last decade or so, with the signings of star players from around the world certainly helping. They get higher average crowds than the NBA and NHL, with the most successful team being LA Galaxy from Los Angeles (5 MLS Cups and 4 Supporters Shields).

MLS Tips, Predictions and Betting advice

It’ll go without saying to a lot of folks out there, but you should probably look for the superstars. Whilst the likes of Wayne Rooney, Carlos Vela and Zlatan Ibrahimovic aren’t going to single-handedly lead their team to victory every week, they’re certainly going to play influential roles. With that in mind, you should take a real hard look at the starting XIs – because defensively speaking, there’s a lot of vulnerability on display in the MLS.

Tough and rough playing style

In addition to that, you should prepare for quite a few yellow and red cards throughout the course of most game weeks. These guys go in pretty hard on a regular basis, and with that kind of intensity, MLS tips that are based on standard play could go flying out of the window.

Mainly, though, when it comes to your MLS football predictions, keep an eye on momentum, because the American sports franchises thrive off of big runs late in the season. The allure of the playoffs always leads to teams upping their game, so if you’re betting late in the campaign, make sure to keep that in mind.

Our Team Of MLS Experts

Despite Major League Soccer still being in its infancy when compared to some of the other major leagues situated around world football, we’ve still been able to build up a solid collection of experts that provide top MLS tips from the first week of the season right up until the very last.

They’re located around the United States and beyond, with one of their primary tools being their ability to compare and contrast the American style with the European style. In addition to that, they also monitor the ‘lower leagues’ of American football pretty closely, which is especially important when you see some of these expansion franchises being brought into the mix.

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